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- The recommended starting dose: 75 mg/day, administered
in a single dose.
- For some patients, it may be desirable to start at 37.5
mg/day for 4 to 7 days, to allow new patients to adjust
to the medication before increasing to 75 mg/day.
- If after several weeks further clinical improvement
is required, the dose may be increased to 150mg per day
given. Patients not responding to
the initial 75mg/day dose may benefit from dose increases
to a maximum of approximately 225 mg/day.
- Dose increases should be in increments of up to 75 mg/day,
as needed, and should be made at intervals of not less
than 4 days, since steady state plasma levels of venlafaxine
and its major metabolites are achieved in most patients
by day 4. |
